Colchicine controversy.

ST056390 Colchicine

REFERENCE: Reference Luduena, R.F., et al., Tubulin structure and biochemistry. Curr. Opin. Cell Biol. 4, 53-57, (1992) abstract Andreu, J.M., et al., Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. Biochemistry 37, 8356-8368, (1998) abstract Suzuki, Y, Cell death, phagocytosis, and neurogenesis in mouse olfactory epithelium and vomeron...

Screening for prostate cancer: Controversy? What controversy?

for the absence of a reduction in mortality in the plco trial and in comparison with the difference seen in the erspc trial. The truth of the matter is the psa test should not be used at all in screening for prostate cancer in the manner it has heretofore been used. Prostate-specific antigen, discovered in 1970 5,6 , is a normal component of the prostate. It is not cancer-specific. Rather, it i...

Fuelling controversy

The US President’s annual State of the Union speech is a favorite place to unveil new initiatives. For the past several months there has been a buzz that President George W. Bush would say something dramatic about climate change. “Buzz” in Washington can mean political trial balloons, genuine leaks or simply wishful thinking. It took a while to sort out the truth in this case. The week before t...

Hypersensitivity to Colchicine.

Colchicine for acute gout.

Evidence-Based Answer Low-quality evidence shows that low-dose colchicine (up to 1.8 mg over one hour) is an effective therapy for acute gout. However, it has not been compared with nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids in clinical trials. Concerns include high cost, drug-drug interactions, and potential toxicity. (Strength of Recommendation: B, based on inconsistent ...